Cladribine in the treatment of systemic lupus erythematosus nephritis.

نویسندگان

  • V Kontogiannis
  • P C Lanyon
  • R J Powell
چکیده

Systemic lupus erythematosus (SLE) nephritis often requires treatment with cyclophosphamide, which carries the risk of major side eVects including infection, ovarian failure and bladder malignancy. Therapeutic strategies that would specifically target lymphocytes are appealing. Following the first report of the use of the purine nucleoside analogue cladribine (2-chloro-2’deoxyadenosine), a selective lymphocyte depleting agent, in the treatment of lupus nephritis, we report our experience in two patients with severe renal involvement.

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عنوان ژورنال:
  • Annals of the rheumatic diseases

دوره 58 10  شماره 

صفحات  -

تاریخ انتشار 1999